Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis
Weihua Bian, Xiaohong Jing, Zhiyu Yang, Zhen Shi, Ruiyao Chen, Ai-Li Xu, Na Wang, Jing Jiang, Cheng Yang, Daolai Zhang, Lan Li, Haiyan Wang, Juan Wang, Yeying Sun, Chunxiang Zhang
Abstract
mice, NORAD-knockdown increased the lipid disorder and atherosclerotic lesions. The results have suggested that lncRNA NORAD attenuates endothelial cell senescence, endothelial cell apoptosis, and atherosclerosis via NF-κB and p53-p21 signaling pathways and IL-8, in which NORAD-mediated effect on IL-8 might through the direct interaction with SFPQ.
Topics & Concepts
Gene knockdownViability assayDownregulation and upregulationApoptosisCell cycleBiologyCancer researchCellCell biologyCell growthUmbilical veinChemistryIn vitroBiochemistryGeneCancer-related molecular mechanisms researchAtherosclerosis and Cardiovascular Diseases