The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
Ji‐Yeun Hur, Georgia Frost, Xianzhong Wu, Christina J. Crump, Si Pan, Eitan Wong, Marilia Barros, Thomas Li, Pengju Nie, Yujia Zhai, Jen Chyong Wang, Julia TCW, Lei Guo, Andrew McKenzie, Ming Chen, Xianxiao Zhou, Minghui Wang, Yotam Sagi, Alan E. Renton, Bianca Esposito, Yong Kim, Katherine R. Sadleir, Ivy Trinh, Robert A. Rissman, Robert Vassar, Bin Zhang, Douglas S. Johnson, Eliezer Masliah, Paul Greengard, Alison Goate, Yue‐Ming Li
Topics & Concepts
Innate immune systemNeuroinflammationAmyloid precursor proteinAmyloid (mycology)Cell biologyInflammationTransmembrane proteinBACE1-ASDownregulation and upregulationAlzheimer's diseaseGenetically modified mouseChemistryAmyloid precursor protein secretaseTransgeneImmune systemDiseaseBiologyImmunologyMedicineGeneBiochemistryInternal medicineReceptorInorganic chemistryNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancerAlzheimer's disease research and treatments