Targeting Multidrug-Recalcitrant Pseudomonas aeruginosa Biofilms: Combined-Enzyme Treatment Enhances Antibiotic Efficacy
Yixin Zhang, Wei Wei, Huamei Wen, Zhongle Cheng, Zhongwen Mi, Jing Zhang, Xiaolong Liu, Xinjiong Fan
Abstract
to disrupt biofilms. Interestingly, under the combined-enzyme intervention for P. aeruginosa wild-type strain PAO1 and clinical strains, no biofilm was observed on the bottom of NEST glass-bottom cell culture dishes. The combination strategy also helped multidrug-resistant clinical strains change from resistant to intermediate or sensitive to many antibiotics commonly used in clinical practice. These results demonstrated that the combined-enzyme approach for inhibiting biofilms is a potential clinical treatment for P. aeruginosa infection.
Topics & Concepts
Pseudomonas aeruginosaAntibioticsBiofilmMicrobiologyMultiple drug resistanceMultidrug toleranceChemistryMedicineBiologyBacteriaGeneticsBacterial biofilms and quorum sensingAntibiotic Resistance in BacteriaAntimicrobial Peptides and Activities