Journey of Von Hippel-Lindau (VHL) E3 ligase in PROTACs design: From VHL ligands to VHL-based degraders
Nisha Setia, Haider Thaer Abdulhameed Almuqdadi, Mohammad Abid
Topics & Concepts
Ubiquitin ligaseDruggabilityUbiquitinDrug discoveryProteasomeDNA ligaseComputational biologyProtein degradationChemistryUbiquitin-Protein LigasesBiologyBiochemistryDNAGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments