Alteration of Lung and Gut Microbiota in IL-13-Transgenic Mice Simulating Chronic Asthma
Kyoung‐Hee Sohn, Min-gyung Baek, Sung-Mi Choi, Boram Bae, Ruth Yuldam Kim, Young Chan Kim, Hye Young Kim, Hana Yi, Hye‐Ryun Kang
Abstract
significantly affected the alpha diversity of both lung and gut microbiomes. In summary, chronic asthma-like pathologic changes can alter the lung microbiota and affect the gut microbiome. These findings suggest that the lung-gut microbial axis might actually work in asthma.
Topics & Concepts
TransgeneAsthmaGut floraGenetically modified mouseLungImmunologyInternal medicineMedicineBiologyEndocrinologyGeneGeneticsIL-33, ST2, and ILC PathwaysAsthma and respiratory diseasesPediatric health and respiratory diseases