Pd/C-Catalyzed transfer hydrogenation of <i>N</i>–H indoles with trifluoroethanol and tetrahydroxydiboron as the hydrogen source
Xiaoyu Zhou, Xia Chen
Abstract
), Pd/C catalyzed transfer hydrogenation of N-H indoles with trifluoroethanol and tetrahydroxydiborane as the hydrogen source has been developed. This provides an efficient strategy and catalytic system for the reduction of un-activated N-H indoles, and N-H indolines are obtained with good to excellent yields. In addition, a series of the isotopic labelling experiments were carried out to probe the mechanism.
Topics & Concepts
Transfer hydrogenationCatalysisChemistryHydrogenNoyori asymmetric hydrogenationCatalytic hydrogenationOrganic chemistryMedicinal chemistryCombinatorial chemistryRutheniumAsymmetric Hydrogenation and CatalysisOrganoboron and organosilicon chemistryChemical Synthesis and Analysis