Placental trophoblast cell-derived exosomal microRNA-1290 promotes the interaction between endometrium and embryo by targeting LHX6
Shuang Shi, Qiang Tan, Jingjie Liang, Dingren Cao, Shaoyu Wang, Junyong Liang, Kaiyu Chen, Zhengguang Wang
Abstract
. More importantly, by targeting LHX6, trophoblast HTR8/SVneo cell-derived exosomal miR-1290 promoted the EMT process of endometrial epithelial cell HEC-1-A. Altogether, our findings provide novel insights into the mechanism of trophoblast cell-derived exosomes during embryo implantation.
Topics & Concepts
TrophoblastCell biologyEmbryomicroRNAEndometriumMicrovesiclesCellBiologyCancer researchAndrologyPlacentaMedicinePregnancyFetusEndocrinologyGeneticsGeneReproductive System and PregnancyPregnancy and preeclampsia studiesExtracellular vesicles in disease