APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer’s disease pathology
Augustine Chemparathy, Yann Le Guen, Sunny Chen, Eun-Gyung Lee, Lesley Leong, John E. Gorzynski, Tanner Jensen, Alexis Ferrasse, Guangxue Xu, Hong Xiang, Michaël E. Belloy, Nandita Kasireddy, Andrés Peña‐Tauber, Kennedy Williams, Ilaria Stewart, Lia Talozzi, Thomas S. Wingo, James J. Lah, Suman Jayadev, Chadwick M. Hales, Elaine R. Peskind, Daniel D. Child, Sigrun Roeber, C. Dirk Keene, Le Cong, Euan A. Ashley, Chang‐En Yu, Michael D. Greicius
Topics & Concepts
DiseaseLongevityApolipoprotein ELoss functionAlzheimer's diseaseFunction (biology)NeuroscienceBiologyMedicinePathologyGerontologyPhenotypeGeneticsGeneMitochondrial Function and PathologyGenomics and Rare DiseasesGenetic Neurodegenerative Diseases