Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms
Xia Zhao, Jing Wang, Liying Tang, Pei Li, Jing Ru, Yuzhi Bai
Abstract
study revealed that WFA notably ameliorated UA-induced cell fibrosis and apoptosis. Taken together, WFA improves kidney function by decreasing UA via regulation of XOD and transporter genes in renal tubular cells.
Topics & Concepts
HyperuricemiaKidneyChemistryOrganic anion transporter 1FibrosisUric acidXanthine oxidaseApoptosisCreatininePharmacologyRenal functionBlood urea nitrogenEndocrinologyInternal medicineBiochemistryMedicineTransporterEnzymeGeneGout, Hyperuricemia, Uric AcidInflammasome and immune disordersBone and Joint Diseases