Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways
Ramin S. Herati, Luisa Victoria Silva, Laura A. Vella, Alexander Muselman, Cécile Alanio, Bertram Bengsch, Raj K. Kurupati, Senthil Kannan, Sasikanth Manne, Andrew V. Kossenkov, David H. Canaday, Susan A. Doyle, Hildegund C.J. Ertl, Kenneth E. Schmader, E. John Wherry
Abstract
cTfh display strong enrichment for signatures of underlying age-associated biological changes. These data highlight the ability to use vaccine-induced cTfh as cellular "biosensors" of underlying inflammatory and/or overall immune health.
Topics & Concepts
CD38Immune systemImmunologyTumor necrosis factor alphaVaccinationImmunityBiologyInflammationHumoral immunityAntibodyVirologyCell biologyStem cellCD34T-cell and B-cell ImmunologyImmune Cell Function and InteractionNeuroinflammation and Neurodegeneration Mechanisms