Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Lennart Schlaphoff, Constanze Depp, Tim Düking, Jan Winchenbach, Jonathan Neuber, David Ewers, Patricia Scholz, Franziska van der Meer, Ludovico Cantuti‐Castelvetri, Andrew Octavian Sasmita, Martin Meschkat, Torben Ruhwedel, Wiebke Möbius, Roman Sankowski, Marco Prinz, Inge Huitinga, Michael W. Sereda, Francesca Odoardi, Till Ischebeck, Mikael Simons, Christine Stadelmann, Julia M. Edgar, Klaus‐Armin Nave, Gesine Saher
Topics & Concepts
MicrogliaRemyelinationDesmosterolMyelinNPC1Multiple sclerosisLiver X receptorCell biologyBiologyCholesterolInflammationOligodendrocyteSterolNeuroscienceImmunologyCentral nervous systemBiochemistryTranscription factorEndosomeGeneNuclear receptorIntracellularCholesterol and Lipid MetabolismNeuroinflammation and Neurodegeneration MechanismsPeroxisome Proliferator-Activated Receptors