Editorial: Control of Regulatory T Cell Stability, Plasticity, and Function in Health and Disease

Abstract

Regulatory T cells (CD4 + CD25 high CD127 -FOXP3 + , Tregs) play a fundamental role in maintaining immune homeostasis by modulating the immune response against self-antigens, allergens, pathogens, and tumors. While Tregs were originally thought to be a terminally differentiated population of T cells whose only function was to inhibit the activation and/or proliferation of other immune cells, studies over the past decade have established that Tregs are a more plastic and dynamic population than previously thought and they have a far broader role mediated by their interaction with several immune and non-immune cells.

Topics & Concepts