The regulation of cell metabolism by hypoxia and hypercapnia
Ben Reddan, Eoin P. Cummins
Abstract
, introduces metabolic adaptations within the aerobic metabolism pathways, affecting tricarboxylic acid cycle flux, lipid, and amino acid metabolism, oxidative phosphorylation and the electron transport chain. Hypoxia, defined by reduced oxygen availability, necessitates a shift from oxidative phosphorylation to anaerobic glycolysis to sustain ATP production, a process orchestrated by the stabilization of hypoxia-inducible factor-1α. Given that hypoxia and hypercapnia are present in both physiological and cancerous microenvironments, how might the coexistence of hypercapnia and hypoxia influence metabolic pathways and cellular function in physiological niches and the tumor microenvironment?
Topics & Concepts
HypercapniaHypoxia (environmental)MetabolismCell metabolismChemistryOxygen metabolismCell biologyBiologyBiochemistryOxygenAnatomyRespiratory systemOrganic chemistryMitochondrial Function and PathologyCancer, Hypoxia, and MetabolismAdipose Tissue and Metabolism