Activation of the Akt1-CREB pathway promotes <i>RNF146</i> expression to inhibit PARP1-mediated neuronal death
Hyojung Kim, Jisoo Park, Hojin Kang, Seung Pil Yun, Yun‐Song Lee, Yun‐Il Lee, Yunjong Lee
Abstract
Akt1-activating compounds such as the polyphenol chlorogenic acid may prevent neuronal death in Parkinson’s disease.
Topics & Concepts
CREBPARP1AKT1Cell biologySignal transductionBiologyCancer researchChemistryNeuroscienceTranscription factorGeneticsPI3K/AKT/mTOR pathwayGenePoly ADP ribose polymerasePolymerasePARP inhibition in cancer therapyCRISPR and Genetic EngineeringCardiac electrophysiology and arrhythmias