Renalase Prevents Renal Fibrosis by Inhibiting Endoplasmic Reticulum Stress and Down-Regulating GSK-3β/Snail Signaling
Yiru Wu, Yu Bai, Yiduo Feng, Qidong Zhang, Zongli Diao, Wenhu Liu
Abstract
Renalase prevents renal fibrosis by down-regulating GSK-3β/Snail signaling through inhibition of ER stress. Exogenous Renalase may be an effective method of slowing or stopping chronic kidney disease progression.
Topics & Concepts
SnailUnfolded protein responseEndoplasmic reticulumFibrosisGSK-3EndocrinologyInternal medicineMedicineSignal transductionBiologyCell biologyEcologyMicrobial metabolism and enzyme functionChronic Kidney Disease and DiabetesTissue Engineering and Regenerative Medicine