Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect
Tarek S. Ibrahim, Mohamed M. Hawwas, Azizah M. Malebari, Ehab S. Taher, Abdelsattar M. Omar, Thikryat Neamatallah, Zakaria K. Abdel‐Samii, Martin K. Safo, Yaseen A. M. M. Elshaier
Abstract
/M phase, effectively inducing apoptosis and inhibition of cell migration.
Topics & Concepts
TubulinCombretastatinQuinolineApoptosisChemistryMicrotubuleStereochemistryStructure–activity relationshipPharmacologyIn vitroBiochemistryBiologyCell biologyOrganic chemistrySynthesis and biological activityClick Chemistry and ApplicationsMetal complexes synthesis and properties