Exploration of Human Serum Lipoprotein Supramolecular Phospholipids Using Statistical Heterospectroscopy in <i>n</i>-Dimensions (SHY-<i>n</i>): Identification of Potential Cardiovascular Risk Biomarkers Related to SARS-CoV-2 Infection
Reika Masuda, Samantha Lodge, Luke Whiley, Nicola Gray, Nathan G. Lawler, Philipp Nitschke, Sze-How Bong, Torben Kimhofer, Ruey Leng Loo, Berin A. Boughton, Annie Xu Zeng, Drew A. Hall, Hartmut Schaefer, Manfred Spraul, Girish Dwivedi, Bu B. Yeap, Tammo Diercks, Ganeko Bernardo‐Seisdedos, José M. Mato, John C. Lindon, Elaine Holmes, Óscar Millet, Julien Wist, Jeremy K. Nicholson
Abstract
= 0.86) with the apolipoprotein B100/A1 ratio, a well-established marker of cardiovascular disease risk that is markedly elevated during acute SARS-CoV-2 infection. These data indicate the considerable potential of using a serum SPC measurement as a metric of cardiovascular risk based on a single NMR experiment. This is of specific interest in relation to understanding the potential for increased cardiovascular risk in COVID-19 patients and risk persistence in post-acute COVID-19 syndrome (PACS).