Central GLP-1 contributes to improved cognitive function and brain glucose uptake after duodenum-jejunum bypass on obese and diabetic rats
Rexiati Ruze, Qian Xu, Guoqin Liu, Yuekai Li, Weijie Chen, Zhiqiang Cheng, Yacheng Xiong, Shaozhuang Liu, Guangyong Zhang, Sanyuan Hu, Zhibo Yan
Abstract
The improvement of cognitive function following bariatric surgery has been highlighted while its mechanisms remain elusive. The brain glucose uptake of patients was improved after RYGB, and the DJB and sham surgery performed on obese and diabetic Wistar rats revealed that the elevated central GLP-1 contributes to the dramatic improvement of cognitive function, brain glucose uptake, transport, glucose sensing, and neuronal activation.
Topics & Concepts
LiraglutideMedicineInternal medicineGlucose transporterGlucose uptakeEndocrinologyDiabetes mellitusGLUT4Morris water navigation taskGlucagon-like peptide-1Glucose homeostasisDuodenumJejunumInsulinHippocampusInsulin resistanceType 2 diabetesDiabetes Treatment and ManagementBariatric Surgery and OutcomesDiet and metabolism studies