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Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors

Fugui Zhu, Xiangguo Meng, Huixin Liang, Chunquan Sheng, Guoqiang Dong, Dan Liu, Shanchao Wu

2022Bioorganic Chemistry20 citationsDOI

Topics & Concepts

EvodiamineChemistryHistone deacetylaseAcetylationTopoisomeraseHDAC6ApoptosisCell cycle checkpointIn vitroTrichostatin AHistoneCell cycleBiochemistryDNAChromatographyGeneCancer therapeutics and mechanismsHistone Deacetylase Inhibitors ResearchQuinazolinone synthesis and applications
Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors | Litcius