Anthracyclines: biosynthesis, engineering and clinical applications
Mandy B. Hulst, Thadée Grocholski, Jacques Neefjes, Gilles P. van Wezel, Mikko Metsä‐Ketelä
Abstract
Anthracyclines are important anticancer drugs. We discuss recent insights into the biosynthetic pathways and bioactivities of anthracyclines, and evaluate the discovery and engineering of effective derivatives with less severe side effects.
Topics & Concepts
Computational biologyBiosynthesisChemistryPharmacologyCombinatorial chemistryBiologyBiochemistryGeneCancer therapeutics and mechanismsMicrobial Natural Products and BiosynthesisCancer Treatment and Pharmacology