SEDT2/METTL14-mediated m6A methylation awakening contributes to hypoxia-induced pulmonary arterial hypertension in mice
Xueliang Zhou, Feng-Jian Huang, Yang Li, Huang Huang, Qicai Wu
Abstract
A RNA methylation level in PAH SMCs. These results obtained from mice suggest that strategies that target the inhibition of SETD2/METTL14 activity may be a viable treatment for PAH in a clinical setting.
Topics & Concepts
Hypoxia (environmental)Pulmonary hypertensionCardiologyMedicineMethylationInternal medicineBiologyChemistryOxygenGeneticsGeneOrganic chemistryRNA modifications and cancerHVDC Systems and Fault ProtectionCancer-related gene regulation