Direct Measurement of Interhelical DNA Repulsion and Attraction by Quantitative Cross-Linking
I. D. Hamilton, Magdalena Gębala, Daniel Herschlag, Rick Russell
Abstract
concentrations and net attraction at higher concentrations, without the higher-order DNA condensation that typically complicates studies of helical attraction. Our measurements define the relevant distances for electrostatic interactions of nucleic-acid helices in biology and introduce a new method to propel further understanding of how these forces impact biological processes.
Topics & Concepts
ChemistryElectrostaticsNucleic acidDNAFolding (DSP implementation)Chemical physicsHelix (gastropod)Ionic bondingCrystallographyDNA condensationAttractionStatic electricityIonPhysical chemistryPhysicsBiochemistryOrganic chemistryLinguisticsPhilosophyBiologyEngineeringElectrical engineeringSnailGeneEcologyQuantum mechanicsTransfectionDNA and Nucleic Acid ChemistryNanopore and Nanochannel Transport StudiesElectrostatics and Colloid Interactions