N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents
Jiedan Deng, Lin Long, Peng Xue, Weifan Jiang, Ying Peng, Xi Zhang, Yuting Zhao, Ying Tian, Zhen Wang, Linsheng Zhuo
Topics & Concepts
EvodiamineChemistryTubulinTopoisomeraseIC50PharmacologyCell cultureCell cycleIn vitroNatural productStructure–activity relationshipApoptosisBiological activityCancer researchMicrotubuleBiochemistryBiologyCell biologyGeneticsChromatographyCancer therapeutics and mechanismsQuinazolinone synthesis and applicationsSynthesis and Biological Evaluation