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Role of charged residues of the “electrostatic loop” of hSOD1 in promotion of aggregation: Implications for the mechanism of ALS-associated mutations under amyloidogenic conditions

Elaheh Mavadat, Bagher Seyedalipour, Saman Hosseinkhani, Abasalt Hosseinzadeh Colagar

2023International Journal of Biological Macromolecules26 citationsDOI

Topics & Concepts

MutantProtein aggregationChemistryAmyloid (mycology)BiophysicsFluorescence correlation spectroscopyFluorescenceStatic electricityWild typeMutationSOD1Circular dichroismBiochemistryGeneBiologyEngineeringMoleculePhysicsQuantum mechanicsOrganic chemistryInorganic chemistryElectrical engineeringAmyotrophic Lateral Sclerosis ResearchPrion Diseases and Protein MisfoldingAlzheimer's disease research and treatments
Role of charged residues of the “electrostatic loop” of hSOD1 in promotion of aggregation: Implications for the mechanism of ALS-associated mutations under amyloidogenic conditions | Litcius