Failures to Replicate: What Recent Negative Phase 3 Trials Have Taught Us about Amyotrophic Lateral Sclerosis Clinical Research
Jeremy M. Shefner, Merit Cudkowicz
Abstract
J.M.S. has received research funding and personal compensation for consulting from Cytokinetics, Amylyx Pharmaceuticals, MT Pharma, and Biogen. M.E.C. has received institutional research grant funding from Amylyx Pharmaceuticals and Cytokinetics, and personal compensation from Cytokinetics, MT Pharma, and Biogen. [Correction added on June 27, 2024, after initial online publication: The preceding sentence has been revised in this version.]
Topics & Concepts
Amyotrophic lateral sclerosisCompensation (psychology)ReplicateClinical trialMedicinePsychologyInternal medicineDiseaseSocial psychologyStatisticsMathematicsAmyotrophic Lateral Sclerosis ResearchPrion Diseases and Protein Misfoldingbiodegradable polymer synthesis and properties