Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways
Hana Lee, Ye Seul Son, Mi‐Ok Lee, Jea-Woon Ryu, Kunhyang Park, Ohman Kwon, Kwang Bo Jung, Kwangho Kim, Tae Young Ryu, Aruem Baek, Janghwan Kim, Cho‐Rok Jung, Choong‐Min Ryu, Young‐Jun Park, Tae-Su Han, Dae‐Soo Kim, Hyun‐Soo Cho, Mi‐Young Son
Abstract
: The results of our study suggest that low-dose IL-2 has therapeutic effects on DSS-induced colitis and potential clinical value in treating UC.
Topics & Concepts
Protein kinase BColitisPI3K/AKT/mTOR pathwayChemistryInterleukinSignal transductionPharmacologyCancer researchMedicineImmunologyBiochemistryCytokineHelicobacter pylori-related gastroenterology studiesImmune Cell Function and InteractionGastrointestinal motility and disorders