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Synthesis of tetrasubstituted thiophenes <i>via</i> a [3+2] cascade cyclization reaction of pyridinium 1,4-zwitterionic thiolates and activated allenes

Shengxian Zhai, Xinping Zhang, Bin Cheng, Hui Li, Yuntong Li, Yixuan He, Yun Li, Taimin Wang, Hongbin Zhai

2020Chemical Communications69 citationsDOI

Abstract

A [3+2] cascade cyclization reaction of pyridinium 1,4-zwitterionic thiolates and activated allenes has been developed, which allows facile access to a library of tetrasubstituted thiophenes with great variety under thermal conditions.

Topics & Concepts

PyridiniumCascadeChemistryCombinatorial chemistryCascade reactionMedicinal chemistryOrganic chemistryCatalysisChromatographySulfur-Based Synthesis TechniquesCatalytic Alkyne ReactionsCyclopropane Reaction Mechanisms
Synthesis of tetrasubstituted thiophenes <i>via</i> a [3+2] cascade cyclization reaction of pyridinium 1,4-zwitterionic thiolates and activated allenes | Litcius