Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo
Ji Liu, Tianyu Ma, Rui Yao, Lei Li, Qizhen Zheng, Ming Wang
Topics & Concepts
In vivoBiologyProtein degradationCell biologyUbiquitin ligaseSupramolecular chemistryDegradation (telecommunications)Computational biologyFunction (biology)HEK 293 cellsModular designIn vitroProtein–protein interactionTarget proteinSupramolecular assemblyBiophysicsProtein stabilityUbiquitinPlasma protein bindingSynthetic biologyScaffold proteinProtein functionUbiquitin-Protein LigasesDNA ligaseNanotechnologyF-box proteinSystems biologyBiochemistryProtein structureMolecular biologyProtein Degradation and InhibitorsClick Chemistry and ApplicationsPeptidase Inhibition and Analysis