Quinazolinone-based benzenesulfonamides with low toxicity and high affinity as monoamine oxidase-A inhibitors: Synthesis, biological evaluation and induced-fit docking studies
Cem Yamalı, Halise İnci Gül, Mehtap Tuğrak Sakarya, Begüm Nurpelin Sağlık, Abdulilah Ece, Göksun Demirel, Merve Nenni, Serkan Levent, Ahmet Cihat ÖNER
Topics & Concepts
ChemistryMonoamine oxidaseMoclobemideDocking (animal)In silicoIC50StereochemistryEnzymeLipinski's rule of fivePharmacologyMonoamine neurotransmitterToxicityMonoamine oxidase BBiochemistryIn vitroReceptorOrganic chemistryMedicineBiologyAntidepressantNeuroscienceHippocampusGeneSerotoninNursingCholinesterase and Neurodegenerative DiseasesElectrochemical sensors and biosensorsEnzyme function and inhibition