Synthesis of Indolizines from Pyridinium Salts and Ethyl Bromodifluoroacetate
Xiaoya Hou, Sen Zhou, Yuli Li, Minjie Guo, Wentao Zhao, Xiangyang Tang, Guangwei Wang
Abstract
Here we present a novel annulation of pyridinium salts with BrCF2CO2Et to access the indolizine derivatives with high efficiency. The α substitution of pyridine plays a key role in determining the reaction pathways. Various types of indolizines can be conveniently accessed from easily available pyridinium salts under mild and simple reaction conditions.
Topics & Concepts
IndolizinePyridiniumChemistryPyridineAnnulationPyridinium CompoundsCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalysisSynthesis and Reactivity of HeterocyclesCyclopropane Reaction MechanismsSynthesis and Characterization of Pyrroles