Acute kidney injury biomarkers and hydration assessments following prolonged mild hypohydration in healthy young adults
Christopher L. Chapman, Sadie M. Holt, Cameron T. O’Connell, Shaun C. Brazelton, William Howells, Hannah N. Medved, Emma L. Reed, Karen Wiedenfeld Needham, John R. Halliwill, Christopher T. Minson
Abstract
This study found that prolonged mild hypohydration in healthy young adults increased the Food and Drug Administration approved acute kidney injury (AKI) biomarker urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase-2 [IGFBP7·TIMP-2]. Urine osmolality and specific gravity demonstrated an excellent ability to discriminate positive AKI risk. These findings emphasize the importance of hydration in protecting renal health and lend early support for hydration assessment as an accessible tool to assess AKI risk.
Topics & Concepts
Acute kidney injuryMedicineBiomarkerUrinary systemUrineFood and drug administrationInternal medicineKidneyDrugUrologyIntensive care medicinePharmacologyBiologyBiochemistryThermoregulation and physiological responsesClimate Change and Health ImpactsElectrolyte and hormonal disorders