Effects of passive and active leg movements to interrupt sitting in mild hypercapnia on cardiovascular function in healthy adults
Song‐Young Park, TeSean K. Wooden, Elizabeth J. Pekas, Cody Anderson, Santosh K. Yadav, Dustin Slivka, Gwenaël Layec
Abstract
Passive leg movement could not preserve macrovascular endothelial function, whereas active leg movement could protect endothelial function. Attenuated microvascular function can be salvaged by passive movement and active movement. Preservation of macrovascular hemodynamics and plasma total nitrate/nitrite and endothelin-1 during prolonged sitting requires active movement. These findings dissociate the impacts induced by mechanical stress (passive movement) from the change in metabolism (active movement) on the vasculature during prolonged sitting in a mild hypercapnic environment.
Topics & Concepts
SittingHypercapniaMedicineHemodynamicsCardiologyInternal medicineAnesthesiaRespiratory systemPathologyCardiovascular and exercise physiologyCardiovascular Health and Disease PreventionHeart Rate Variability and Autonomic Control