Serotype Distribution and Antimicrobial Resistance of Streptococcus agalactiae Isolates in Nonpregnant Adults with Streptococcal Toxic Shock Syndrome in Japan in 2014 to 2021
Tadayoshi Ikebe, Rumi Okuno, Yumi Uchitani, Mami Takano, Takahiro Yamaguchi, Hitoshi Otsuka, Yu Kazawa, Shohei Fujita, Ayaka Kobayashi, Yoshimi Date, Junko Isobe, Emi Maenishi, Makoto Ohnishi, Yukihiro Akeda, the Working Group for Beta-Hemolytic Streptococci in Japan, Keiko Ogawa‐Ochiai, Kazuya Mitsuhashi, Takayuki Konno, Kaori Iwabuchi, Takuya Yamanaka, Junji Seto, Mikako Hosoya, Takuhiro Suto, Hiroo Sakai, I. Ogawa, Mayumi Ogawa, Ayano Horikoshi, Miki Matsuyama, Yusuke Yodotani, Chieko Goto, Junko Yoshihara, Kentaro Tomari, Fumie Suzuki, Sae Onoda, Asami Sekikawa, Miki Hikida, Mitsuru Kishizawa, Haruyoshi Kanagawa, Akira Wakatsuki, Akihito Kobayashi, Yuhki Nagai, Tatsuya MATSUDA, Higashi Ogura, Makiko Noda, Ayako Furuta, Emiko Kitagawa, Misa Yoshikawa, Mika Fujikawa, Etsuko Saito, Chikara Nakagawa, Noriko Nakanishi, Yuko Kiguchi, Kayoko Nakaoka, Kayo Aoki, Seiko Umehara, Ryutaro Murayama, Shoko Hirata, Kenkichi Hayashibara, Jun Kawase, Hisahiro Kawai, Takahiro Hiratsuka, Hiroko Akita, Chiiko Yoshida, Yuka Kakumiya, Yukiko Asano, Sayaka Osaki, Atsuko Kageyama, Yuji Migita, Yurika Furukawa, Rika Maeda, Etsuko Nakamura, Tetsuya Kakita, Tsuyoshi Kudeken
Abstract
(GBS) has been increasingly associated with invasive disease in nonpregnant adults. Such infections are responsible for substantial morbidity and mortality, particularly in individuals with underlying chronic conditions. Streptococcal toxic shock syndrome (STSS) is a severe invasive infection characterized by the sudden onset of shock, multiorgan failure, and high mortality. In this study, we assessed 268 GBS-related STSS cases in nonpregnant adults in Japan between 2014 and 2021. Serotype Ib was the most prevalent, followed by serotypes V, III, and Ia, which were identified in more than 80% of STSS isolates. We found that 48 clindamycin-resistant strains and 7 penicillin G-resistant strains were isolated between 2014 and 2021. We believe that our study makes a significant contribution to the literature because we show that the GBS vaccine, particularly the hexavalent conjugate vaccine, is important to reduce the number of patients with STSS.