Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling
Martin Lange, Nils Ohnesorge, Dennis Hoffmann, Susana Rocha, Rui Benedito, Arndt F. Siekmann
Topics & Concepts
ZebrafishBiologyCell biologyAngiogenesisMAPK/ERK pathwaySignal transductionExtracellular matrixVascular endothelial growth factor API3K/AKT/mTOR pathwayProtein kinase BPhosphorylationEndothelial stem cellGene isoformVascular endothelial growth factorCancer researchGeneticsIn vitroVEGF receptorsGeneAngiogenesis and VEGF in CancerZebrafish Biomedical Research ApplicationsHippo pathway signaling and YAP/TAZ