New Micropeptins with Anti-Neuroinflammatory Activity Isolated from a Cyanobacterial Bloom
Riley D. Kirk, Haiyin He, Paul G. Wahome, Shi‐Biao Wu, Guy T. Carter, Matthew J. Bertin
Abstract
) along with the previously characterized micropeptin 996. These metabolites showed potency in anti-neuroinflammatory assays using BV-2 mouse microglial cells, showing a 50% reduction in inflammation in a range from 1 to 10 μM. These results show promise for cyanobacterial peptides in the therapeutic realm apart from their impact on environmental health and provide another example of the utility of large prefractionated natural product libraries for therapeutic hit and lead identification.
Topics & Concepts
Natural productMetaboliteMetabolomicsChemistryPotencyMicrobiomeComputational biologyBiologyIn vitroBiochemistryChromatographyBioinformaticsMarine Sponges and Natural ProductsMicrobial Natural Products and BiosynthesisMetabolomics and Mass Spectrometry Studies