RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity
Ephraim Ansa-Addo, Huai‐Cheng Huang, Brian Riesenberg, Supinya Iamsawat, Davis Borucki, Michelle H. Nelson, Jin Hyun Nam, Dongjun Chung, Chrystal M. Paulos, Bei Liu, Xue‐Zhong Yu, Caroline C. Philpott, Philip H. Howe, Zihai Li
Abstract
RNA binding protein PCBP1 guards effector and antitumor T cell functions.
Topics & Concepts
Immune checkpointImmune systemTIGITBiologyCell biologyEffectorImmunityIntracellularT cellCellImmunologyCancer researchImmunotherapyGeneticsImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersT-cell and B-cell Immunology