Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing
Ramón Garcia-Maset, Victoria Chu, Ka Y. Yuen, Dalia Blumgart, Jenny Yoon, Benjamin Murray, Amelia A. Joseph, Jennifer Rohn
Abstract
Bacterial infections remain a major global health issue, with antimicrobial resistance (AMR) worsening the crisis. However, treatment failure can occur even when bacteria show antibiotic susceptibility in diagnostic tests. We explore factors such as phenotypic resilience, bacterial lifestyles such as biofilms, and differences between laboratory tests and real infection sites, highlighting the need for improved platforms to better predict treatment outcomes, and reviewing emerging technologies aimed at improving susceptibility testing.
Topics & Concepts
Antibiotic resistanceHost (biology)BiologyResilience (materials science)Host responseAntibioticsAntimicrobialMicrobiologyImmunologyImmune systemGeneticsThermodynamicsPhysicsBacterial Identification and Susceptibility TestingAntibiotic Resistance in BacteriaGut microbiota and health