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Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease

Joonhong Jun, Songyi Yang, Jung-Hun Lee, Hyungwoo Moon, Jinwoong Kim, Hoyong Jung, Daseul Im, Youri Oh, Miyoung Jang, Hyunwook Cho, Jihyun Baek, Hyejin Kim, Dahyun Kang, Hyunah Bae, Chanwool Tak, Kyungrim Hwang, Ho‐Seok Kwon, HyunTae Kim, Jung‐Mi Hah

2022European Journal of Medicinal Chemistry26 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryGene isoformKinaseIn vivoProtein kinase AAlzheimer's diseasePharmacologyImidazoleIC50In vitroBiochemistryNeuroscienceDiseaseBiologyInternal medicineMedicineGeneGeneticsComputational Drug Discovery MethodsCholinesterase and Neurodegenerative DiseasesMelanoma and MAPK Pathways
Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease | Litcius