Aromatization as an Impetus to Harness Ketones for Metallaphotoredox-Catalyzed Benzoylation/Benzylation of (Hetero)arenes
Shao‐Chi Lee, Liyun Li, Zong‐Nan Tsai, Yi-Hsin Lee, Yong‐Ting Tsao, Pin-Gong Huang, Cheng-Ku Cheng, Heng-Bo Lin, Tingwei Chen, Chung-Hsin Yang, Cheng‐chau Chiu, Hsuan‐Hung Liao
Abstract
Herein we report ketones as feedstock materials in radical cross-coupling reactions under Ni/photoredox dual catalysis. In this approach, simple condensation first converts ketones into prearomatic intermediates that then act as activated radical sources for cross-coupling with aryl halides. Our strategy enables the direct benzylation/benzoylation of (hetero)arenes under mild reaction conditions with high functional group tolerance.
Topics & Concepts
ChemistryAromatizationArylCatalysisHalideOrganic chemistryFunctional groupCombinatorial chemistryCoupling reactionAlkylPolymerRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques