Controlling the pyridinium–zwitterionic ligand ratio on atomically precise gold nanoclusters allowing for eradicating Gram-positive drug-resistant bacteria and retaining biocompatibility
Zeyang Pang, Qizhen Li, Yuexiao Jia, Weixiao Yan, Jie Qi, Yuan Guo, Fupin Hu, Dejian Zhou, Xingyu Jiang
Abstract
and animal models of skin infections. Furthermore, the fluorescence of the gold nanocluster at the second near-infrared (NIR-II) biological window allowed for the monitoring of its biodistribution and body clearance, which confirmed that the gold nanoclusters had good renal clearance and biocompatibility. This study provides a new strategy to combat the MDR challenge using multifunctional gold nanomaterials.
Topics & Concepts
NanoclustersBiocompatibilityLigand (biochemistry)BiodistributionMultiple drug resistanceBacteriaChemistryAntibacterial activityCombinatorial chemistryNanotechnologyMaterials scienceBiophysicsAntibioticsIn vitroBiochemistryBiologyReceptorOrganic chemistryGeneticsNanocluster Synthesis and ApplicationsAdvanced Nanomaterials in CatalysisPharmacological Effects and Toxicity Studies