Insular and occipital changes in visual snow syndrome: a BOLD fMRI and MRS study
Francesca Puledda, Dominic ffytche, David J. Lythgoe, Owen O’Daly, Christoph J. Schankin, Steven Williams, Peter J. Goadsby
Abstract
Abstract Objective To investigate the pathophysiology of visual snow (VS), through a combined functional neuroimaging and magnetic resonance spectroscopy ( 1 H‐MRS) approach. Methods We applied a functional MRI block‐design protocol studying the responses to a visual stimulation mimicking VS, in combination with 1 H‐MRS over the right lingual gyrus, in 24 patients with VS compared to an equal number of age‐ and gender‐matched healthy controls. Results We found reduced BOLD responses to the visual stimulus with respect to baseline in VS patients compared to controls, in the left ( k = 291; P = 0.025; peak MNI coordinate [‐34 12 ‐6]) and right ( k = 100; P = 0.003; peak MNI coordinate [44 14 ‐2]) anterior insula. Our spectroscopy analysis revealed a significant increase in lactate concentrations in patients with respect to controls (0.66 ± 0.9 mmol/L vs. 0.07 ± 0.2 mmol/L; P < 0.001) in the right lingual gyrus. In this area, there was a significant negative correlation between lactate concentrations and BOLD responses to visual stimulation ( P = 0.004; r = −0.42), which was dependent on belonging to the patient group. Interpretation As shown by our BOLD analysis, VS is characterized by a difference in bilateral insular responses to a visual stimulus mimicking VS itself, which could be due to disruptions within the salience network. Our results also suggest that patients with VS have a localized disturbance in extrastriate anaerobic metabolism, which may in turn cause a decreased metabolic reserve for the regular processing of visual stimuli.