Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode
Robert Shevalev, Luca Bischof, Alexander Sapegin, Alexander S. Bunev, Grigor'eva Olga, Grigory Kantin, Stanislav Kalinin, Marcus D. Hartmann
Topics & Concepts
IsoxazoleMoietyChemistryStereochemistryLinkerLipophilicityCereblonMode of actionCombinatorial chemistryBiochemistryOperating systemUbiquitinUbiquitin ligaseGeneComputer scienceProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways