Effects of Non-insulin Anti-hyperglycemic Agents on Gut Microbiota: A Systematic Review on Human and Animal Studies
Thao T. B. Cao, Kun‐Chang Wu, Jye‐Lin Hsu, Chih‐Shiang Chang, Chiahung Chou, Chen-Yuan Lin, Yu-Min Liao, Pei‐Chun Lin, Liang‐Yo Yang, Hsiang‐Wen Lin
Abstract
The changes in specific taxa and β-diversity of gut microbiota were associated with metformin and acarbose in humans while pertinent information for other anti-hyperglycemic drugs could only be obtained in rodent studies. Further human studies on anti-hyperglycemic drugs other than metformin and acarbose are needed to explore gut microbiota's role in their therapeutic efficacies and side effects.
Topics & Concepts
Akkermansia muciniphilaMetforminGut floraType 2 diabetesAcarboseAkkermansiaBacteroidesAnimal studiesMedicineDiabetes mellitusHuman microbiomeMicrobiomeBiologyInternal medicineDiseaseBioinformaticsEndocrinologyImmunologyBacteriaGeneticsGut microbiota and healthClostridium difficile and Clostridium perfringens researchDiet and metabolism studies