Dual-target regulation of glutathione and heat shock proteins <i>via</i> molecular-carrier-pathway triple-engineering for potentiated phototherapy
Yike Tu, Laiping Fang, Shufang Li, Kuo He, Yanzhao Diao, Lifeng Hang, Lina Wang, Jianan Dai, Ping’an Ma, Guihua Jiang
Abstract
studies revealed that N3@437 under 808 nm laser irradiation achieved 94.9% tumor growth inhibition and markedly suppressed lung metastasis. By employing a triple-pronged strategy of molecular engineering, nanocarrier design, and pathway blockage, this work pioneered a paradigm that concurrently depletes GSH and inhibits HSPs. This breakthrough enables enhanced PDT/PTT performance, offering a transformative solution for combating tumor adaptive resistance.
Topics & Concepts
Dual (grammatical number)Heat shock proteinGlutathioneShock (circulatory)Cell biologyDual roleMaterials scienceChemistryBiophysicsMedicineBiologyBiochemistryInternal medicineCombinatorial chemistryEnzymeGeneLiteratureArtNanoplatforms for cancer theranosticsClick Chemistry and ApplicationsRNA Interference and Gene Delivery