BTK inhibition potentiates anti-PD-L1 treatment in murine melanoma: potential role for MDSC modulation in immunotherapy
Steven Sun, Colin D. Angell, Himanshu Savardekar, Debasish Sundi, David Abood, Brooke Benner, Mallory J. DiVincenzo, Megan Duggan, Fouad Choueiry, Thomas A. Mace, Prashant Trikha, Gabriella Lapurga, Courtney Johnson, Erick J. Carlson, Catherine Chung, Blake R. Peterson, Lianbo Yu, Jing Zhao, Kari Kendra, William E. Carson
Topics & Concepts
Bruton's tyrosine kinaseIbrutinibCancer researchPharmacologyTyrosine kinaseImmune systemMelanomaCancer immunotherapyImmunotherapyChemistryMedicineImmunologySignal transductionLeukemiaChronic lymphocytic leukemiaBiochemistryImmune cells in cancerCancer Immunotherapy and BiomarkersImmune Cell Function and Interaction