The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression
Weifeng Liang, Ming Gu, Lingxiang Zhu, Ziqi Yan, Dominik Schenten, Shelby Herrick, Hongmin Li, Subodh Kumar Samrat, Jiapeng Zhu, Yin Chen
Abstract
SARS-CoV-2 is the etiological cause of COVID-19. RIG-I-like receptor (RLR) signaling pathway appeared to be responsible for SARS-CoV-2 induced IFN, 1 a major antiviral pathway. IFN deficiency 2 , 3 was identified to be a significant risk factor of severe COVID-19, highlighting an important role of IFN in the defense against SARS-CoV-2 and in the pathogenesis of severe COVID-19. Since SARS-CoV-2 is highly susceptible to IFN treatment, 3 , 4 it has to evade host IFN-mediated immune surveillance to establish an active infection,
Topics & Concepts
Innate immune systemPsychological repressionVirologyProteaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ImmunitySars virusCoronavirus disease 2019 (COVID-19)Biology2019-20 coronavirus outbreakImmunologyMedicineEnzymeImmune systemGeneticsBiochemistryInfectious disease (medical specialty)Gene expressionGeneDiseaseOutbreakPathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studiesinterferon and immune responses