hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223
Xiutian Zhang, Peng Tan, Yuan Zhuang, Lei Du
Abstract
Human circular (hsa_circ)RNA_001587 and solute carrier family 4 member 4 (SLC4A4) are poorly expressed but microRNA (miR)R-223 is overexpressed in pancreatic cancer (PC) cells. hsa_circRNA_001587 binds to miR-223. Overexpression of hsa_circRNA_001587 inhibits PC progression. Overexpression of miR-223 downregulates the expression of SLC4A4 and promotes PC cell growth. hsa_circRNA_001587 may be a potential target for PC treatment.
Topics & Concepts
microRNAPancreatic cancerCancer researchAngiogenesisCircular RNAChemistryCancer cellMolecular biologyBiologyCancerGeneBiochemistryGeneticsCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research