Optogenetic Control of the BMP Signaling Pathway
Paul A. Humphreys, Steven Paul Woods, Christopher A. Smith, Nicola Bates, Stuart A. Cain, Robert J. Lucas, Susan J. Kimber
Abstract
. Furthermore, we demonstrate how the optoBMP system can be used to fine-tune activation of the BMP signaling pathway through variable light stimulation. Optogenetic control of BMP signaling will enable dynamic and high-throughput intervention across a variety of applications in cellular and developmental systems.
Topics & Concepts
Bone morphogenetic proteinOptogeneticsBMPR2Signal transductionCell biologyBiologyPhosphorylationBone morphogenetic protein 2GeneticsGeneNeuroscienceIn vitroPluripotent Stem Cells ResearchDevelopmental Biology and Gene RegulationCongenital heart defects research