PSMA-targeted dendrimer as an efficient anticancer drug delivery vehicle for prostate cancer
Anubhav Dhull, Jing Wei, Anunay James Pulukuri, Anu Rani, Rishi Sharma, Nooshin Mesbahi, Hosog Yoon, Emily A. Savoy, Sylvia Xaivong, Kenneth John Goody, Clifford E. Berkman, Boyang Jason Wu, Anjali Sharma
Abstract
We present PD-CTT1298 nanoplatform as a versatile approach for selective systemic delivery of high payloads of potent chemotherapeutics to PSMA (+) prostate cancer, where dose related systemic side-effects are a major concern.
Topics & Concepts
DendrimerProstate cancerDrug deliveryAnticancer drugDrugTargeted drug deliveryCancerMedicineCancer researchNanotechnologyPharmacologyMaterials scienceInternal medicinePolymer chemistryDendrimers and Hyperbranched PolymersRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery