<i>Mycoplasma hyopneumoniae</i> evades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu)
Yanfei Yu, Jia Wang, Rui Han, Li Wang, Lei Zhang, Amy Yimin Zhang, Jiuqing Xin, Shaoli Li, Yanhua Zeng, Guoqing Shao, Zhixin Feng, Qiyan Xiong
Abstract
adhesion to swine tracheal epithelial cells, partially through EF-Tu. Meanwhile, the high sequence identity among EF-Tu proteins in the above-mentioned mycoplasmas implied the universality of the mechanism. This is the first report that mycoplasmas can escape complement killing by binding to factor H.
Topics & Concepts
Mycoplasma hyopneumoniaeBiologyMicrobiologyComplement systemFactor HComplement factor BDecay-accelerating factorMollicutesMycoplasma pneumoniaeComplement factor IVirulence factorMycoplasmaElongation factorMolecular biologyAntibodyBiochemistryImmunologyVirulenceGeneRNAArchaeologyPneumoniaHistoryRibosomeMicrobial infections and disease researchPneumonia and Respiratory InfectionsStreptococcal Infections and Treatments